Further on the Pharmacology of Trichopus Zeylanicus

Oral administration of Trichopus zeylanicus to mice (0.5 ml of 2% water suspension / mouse) for 7 consecutive days markedly increased the number of thymocytes splenic lymphocytes, total blood leucocytes and peritoneal macrophages without any effect on Haemoglobin content and body weight. This increase in the proliferation of lymphocytes and macrophages could be one of the mechanism of T.zeylanicus induced immunomodulation. Treatment with T. zeylanicus protected mice from tumour cell growth when challenged with 0.5 million of EAC ascetic tumour cells / mouse. Studies on the gastrointestinal function of this drug showed that the drug slightly reduced intestinal motility as judged from charcoal movement.